Africa’s research for development (R4D) landscape in West and Central Africa is currently constrained by traditional research approaches that have failed to address complex, interconnected challenges. These approaches have been inadequate in tackling systemic inequalities, knowledge production disparities, and emerging technological and environmental disruptions. The existing research ecosystem requires a fundamental reimagining that can dismantle long-standing unfavorable research methods and create more equitable, connected, and capable research partnerships. The proposed initiative aims to transform the R4D landscape by prioritizing previously overlooked dimensions such as indigenous knowledge, grassroots innovations, and research partnerships that genuinely reflect local realities. By challenging existing power dynamics in knowledge production, creating more inclusive research processes, and developing innovative mechanisms that prioritize development impact, the project seeks to unlock research’s transformative potential. The approach focuses on building local capacities, supporting diverse knowledge systems, and creating flexible, adaptive research frameworks that can drive sustainable development in Central and West Africa.